Establishing a Comprehensive Approach for Uniformly Fair Skin

The cause of dark spots is excessive melanin production that continues even after UV exposure ceases. This phenomenon occurs due to the presence of signaling molecules (endothelin and SCF) that activate and proliferate melanocytes. est has evolved its unique whitening mechanism by focusing on the relationship between melanocytes and these signaling molecules. While previously achieving high whitening effects by suppressing the action of signaling molecules, in Spring 2010, est further evolved by focusing on the 'receptors' on the melanocyte side that bind to these signaling molecules.

The signaling molecule 'SCF,' which is deeply involved in melanocyte proliferation, is produced in keratinocytes and transmits information by binding to receptors on the melanocyte side. Therefore, by suppressing the expression of these receptors, transmission should be blocked. In addition to the conventional approach of reducing 'information transmission' by suppressing SCF expression itself, est has now adopted an approach that also reduces 'reception,' enabling a high inhibitory effect on melanocyte proliferation and activation.

The two new whitening items introduced this time newly incorporate the unique ingredient 'Platycodon grandiflorus root extract,' which suppresses the expression of SCF receptors. The series has been reborn as a more reliable whitening line, exhibiting an even higher melanin production inhibitory effect than before.

Furthermore, based on the concept that 'redness unevenness' caused by hemoglobin makes spots more noticeable, it is formulated with a high concentration of 'Asunaro extract,' known for its potent anti-inflammatory effects. Combined with improved blood circulation and moisturizing effects, it works on the overall skin tone to achieve est's signature uniformly fair skin.

Medicinal Whitening Serum
est Whitening Cross Synergy Essence
Price | ¥10,500
Volume | 30g

A medicinal whitening serum that keeps the entire skin uniformly fair. With a rich, moist texture, it adheres firmly to the skin. It suppresses melanin production, preventing spots and freckles, while providing moisture and leading to smooth skin with refined texture.

Medicinal Whitening Solid Serum
est Whitening Cross Synergy Solid Spots
Price | ¥12,600
Volume | 8.5g

A solid whitening serum that can be layered as desired on concerned areas, allowing whitening ingredients to concentrate. Its firm texture transforms into a cream upon application to the skin. It penetrates deep into the stratum corneum, preventing spots and freckles by inhibiting melanin production.

est
Tel. 03-5630-5040
www.est-net.jp/