Based on the E350 Avantgarde, this edition features a dedicated rear skirt, 18-inch 10-twin-spoke alloy wheels, leather sports seats, and a glass sliding sunroof. It is available exclusively in Iridium Silver for the exterior and Black for the interior.

The E350 Avantgarde is priced at 8.4 million yen, 630,000 yen higher than the base model, with a limited production of 500 units. The E350 Station Wagon Avantgarde costs 8.61 million yen, 462,000 yen more than its base, with 250 units available.