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June 7, 2023
The Next Generation of Anti-Aging Ingredient: What is "NMN," Currently a Hot Topic? | BEAUTY
BEAUTY | NMN
A New Option to Support Future Anti-Aging
Have you heard of "NMN"? It's rapidly becoming a hot topic as a miraculous anti-aging agent with expectations for rejuvenating the body and extending healthy lifespans.
Text by IJICHI Yasutake
Cellular Power is Key to Combating Aging
Many ingredients have garnered attention and popularity in anti-aging over the years. What sets NMN apart from previous ones is that while ingredients like DHA, EPA, glucosamine, and chondroitin targeted the brain, bones, and muscles, NMN targets cells. Andrew Steele's international bestseller "AGLESS" also states that cellular power is key to combating aging. In 2016, Professor Yoshinori Ohsumi, a distinguished professor at the Tokyo Institute of Technology, received the Nobel Prize in Physiology or Medicine for his research on "autophagy," a phenomenon where cells break down and recycle their own components, which was highlighted as a scientific approach to inhibiting aging. There's no doubt that "cells" have become an indispensable key in discussing the mechanisms of aging today.
NMN has been the subject of research at universities and clinical institutions worldwide for the past few years. Its efficacy in improving organ function, preventing diabetes and dementia, and boosting immunity has been demonstrated, along with its safety. The fact that prestigious universities like Harvard, the University of Washington, and in Japan, the University of Tokyo, are involved in this research is likely one of the factors that has boosted its popularity.
So, what exactly is NMN? Its full name is nicotinamide mononucleotide, and it is produced from vitamin B3 as a primary ingredient, naturally occurring in the bodies of all living organisms. NMN is converted in the body into NAD (nicotinamide adenine dinucleotide), a coenzyme necessary for energy production and for inhibiting cellular aging. Once NMN enters the body, it converts to NAD within about 15 minutes, and the optimal daily intake of NMN is said to be 500mg. However, the function of producing NAD declines with age, leading to a decrease in NAD levels in the body. NMN itself is found in foods like vegetables, fruits, and meat, but to obtain 500mg from diet alone, one would need to eat approximately 70-80 kg of broccoli or about 200 kg of meat, which is highly unrealistic. Therefore, the most efficient way to take it is inevitably through supplements. Incidentally, various products and intravenous therapies related to NMN are available, but their efficacy and safety are not guaranteed, and experts are issuing warnings. At present, only oral intake is recommended.
This buzz reminds me of the early days of "CBD" a few years ago when it first appeared in Japan. At that time, early adopters rushed to try it, and opinions were divided on its authenticity, but it's now becoming relatively established. Although the substance is different, "NMN" is currently only in the hands of a select few early adopters, but I believe it will eventually become widespread.
So, how should one choose an NMN supplement?
First, the dosage.
The ideal daily intake suggested by human clinical trials in the US and safety tests on humans at Keio University is 500mg. More is not necessarily better; in fact, excessive amounts can reduce absorption. Therefore, a dosage that provides 500mg per day is optimal.
First, the dosage.
The ideal daily intake suggested by human clinical trials in the US and safety tests on humans at Keio University is 500mg. More is not necessarily better; in fact, excessive amounts can reduce absorption. Therefore, a dosage that provides 500mg per day is optimal.
Second, purity and extraction method.
It is safe to choose products with high purity manufactured in factories certified to maintain quality and produce safely. Even with the same NMN, low purity can lead to adverse effects due to unnecessary bulking agents or additives. This can also happen even if the product claims 99% purity or more. In fact, a US study reported that over 70% of NMN products sold on Amazon did not actually contain NMN.
It is safe to choose products with high purity manufactured in factories certified to maintain quality and produce safely. Even with the same NMN, low purity can lead to adverse effects due to unnecessary bulking agents or additives. This can also happen even if the product claims 99% purity or more. In fact, a US study reported that over 70% of NMN products sold on Amazon did not actually contain NMN.
Third, absorption rate.
It is best to use capsules that are well absorbed in the intestines, allowing NMN's potential to be maximized without being compromised by stomach acid or saliva.
It is best to use capsules that are well absorbed in the intestines, allowing NMN's potential to be maximized without being compromised by stomach acid or saliva.
Finally, synergistic ingredient formulation.
When NMN is combined with ingredients that act on cells and support anti-aging, such as PQQ, Coenzyme Q10, and fisetin, it can lead to an approach that covers the entire process from cellular aging to the removal of senescent cells, thereby enhancing its effects.
When NMN is combined with ingredients that act on cells and support anti-aging, such as PQQ, Coenzyme Q10, and fisetin, it can lead to an approach that covers the entire process from cellular aging to the removal of senescent cells, thereby enhancing its effects.
The market is constantly flooded with products and services related to anti-aging, healthcare, and beauty care, and with a proliferation of unverified information, it is crucial for each individual to have clear criteria for judgment and to be able to select products that suit them.
Mental fulfillment is predicated on physical health. Waking up feeling refreshed, having good skin, feeling agile – when these sensations continue daily, allowing you to truly feel your body's well-being, you can throw yourself fully into both work and play. In an era where we speak of a 100-year lifespan and a future aging society, everyone wants to maintain high performance and enjoy life to the very end. To achieve this, it is essential to engage with one's own body and invest time and money accordingly.
In cooperation with: Recommended NMN Supplements
LUXURY NMN 15000 (Processed food containing NMN)
https://welabo.jp/lp/luxury-nmn-15000/
LUXURY NMN 15000 (Processed food containing NMN)
https://welabo.jp/lp/luxury-nmn-15000/